Treatment Of Fibrous Dysplasia With Zoledronic Acid Infusion Case Report, Review Of Literature And Future Prospectives

Several studies have shown that bisphosphonates are useful in alleviating chronic pain in patients with fibrous dysplasia,but further studies are necessary to confirm these promising results. Being the most potent bisphosphonate we treated one patient of distal femur fibrous dysplasia with Zoledronic acid and would like to share our experience as a case report. 52 years old male patient presented in out-patient department complaining of pain and swelling of left thigh lower aspect for approximately eight months. An open biopsy was performed and diagnosis of fibrous dysplasia was confirmed. Due to location of lesion and financial restraints patient was treated with intravenous Zoledronic acid. There was significant functional improvement and reduction of alkaline phosphatase level to normal within a period of six months. Hence it was considered to report this case as it may add up to the available data of usage of Zoledronic acid in treating fibrous dysplasia.